This book provides in a concrete and comprehensive way indicators that contribute to mapping of regional innovation systems. More specifically, factual analysis on research and innovation in Greek regions is presented through indicators that refer to four thematic axes: a) Research & Development activities, as reflected through the R&D expenditures carried out by the institutions of each Region, b) R&D personnel that is employed and participates in R&D activities, c) the performance of each Regions` bodies and entities in competitive EU R&D projects, scientific publications and doctoral theses, from which international presence, excellence and areas of scientific and technological specialization of the Regions emerge, d) the innovative performance of each Regions` enterprises.